iduronic acid การใช้

• The repeating unit ( except for uronic sugar ( glucuronic acid or iduronic acid ) or galactose.
• For example, L-iduronic acid ( C-5 ) are epimers of glucuronic acid.
• It is not found in nature, but its uronic acid, iduronic acid, is important.
• The three-dimensional structure of heparin is complicated because iduronic acid may be present in either of two low-energy conformations when internally positioned within an oligosaccharide.
• Chondroitin sulfate chains are unbranched polysaccharides of variable length containing two alternating monosaccharides : L-iduronic acid ( IdoA ); the resulting disaccharide is then referred to as dermatan sulfate.
• The enzyme releases 4-deoxy-4, 5-didehydro D-glucuronic acid or 4-deoxy-4, 5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides.
• There is no internationally accepted molecular standard for the composition of heparin, as it is a complex polymer of GAG units and uronic acids ( including D-glucuronic acid, L-iduronic acid, and D-glucosamine ).
• :Endolytic cleavage of beta-1, 4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta 4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta 4-unsaturated tetra-and disaccharides